6I6Z
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH
Replaces: 4UEFSummary for 6I6Z
Entry DOI | 10.2210/pdb6i6z/pdb |
Descriptor | Carboxypeptidase A1, (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | protease, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70195.12 |
Authors | Gallego, P.,Reverter, D. (deposition date: 2018-11-15, release date: 2018-12-12, Last modification date: 2024-10-09) |
Primary citation | Covaleda, G.,Gallego, P.,Vendrell, J.,Georgiadis, D.,Lorenzo, J.,Dive, V.,Aviles, F.X.,Reverter, D.,Devel, L. Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes. J. Med. Chem., 62:1917-1931, 2019 Cited by PubMed: 30688452DOI: 10.1021/acs.jmedchem.8b01465 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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