4UBA
Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)
Summary for 4UBA
Entry DOI | 10.2210/pdb4uba/pdb |
Related | 4UB7 |
Descriptor | Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid (3 entities in total) |
Functional Keywords | protein kinase ck2, atp-competitive inhibitors, halogen bond, 4'-carboxy-6, 8-bromo-flavonol, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P68400 |
Total number of polymer chains | 2 |
Total formula weight | 81013.56 |
Authors | Niefind, K.,Bischoff, N.,Guerra, B.,Golub, A.,Issinger, O.-G. (deposition date: 2014-08-12, release date: 2015-07-01, Last modification date: 2024-05-08) |
Primary citation | Guerra, B.,Bischoff, N.,Bdzhola, V.G.,Yarmoluk, S.M.,Issinger, O.G.,Golub, A.G.,Niefind, K. A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures. Acs Chem.Biol., 10:1654-1660, 2015 Cited by PubMed: 25961323DOI: 10.1021/acschembio.5b00235 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.995 Å) |
Structure validation
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