4U84

Human Pin1 with S-hydroxyl-cysteine 113

Summary for 4U84

• Entry DOI: 10.2210/pdb4u84/pdb
• Related: 4U85 4U86
• Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, POLYETHYLENE GLYCOL (N=34) (3 entities in total)
• Functional Keywords: pin1 oxidation isomerase, isomerase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q13526
• Total number of polymer chains: 1
• Total formula weight: 21756.24

Authors

Li, W.,Zhang, Y. (deposition date: 2014-08-01, release date: 2015-04-08, Last modification date: 2023-12-27)

• Primary citation: Chen, C.H.,Li, W.,Sultana, R.,You, M.H.,Kondo, A.,Shahpasand, K.,Kim, B.M.,Luo, M.L.,Nechama, M.,Lin, Y.M.,Yao, Y.,Lee, T.H.,Zhou, X.Z.,Swomley, A.M.,Allan Butterfield, D.,Zhang, Y.,Lu, K.P.; Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease.; Neurobiol.Dis., 76:13-23, 2015; PubMed: 25576397; DOI: 10.1016/j.nbd.2014.12.027

Experimental method

X-RAY DIFFRACTION (1.78 Å)