4U81
MEK1 Kinase bound to small molecule inhibitor G659
Summary for 4U81
Entry DOI | 10.2210/pdb4u81/pdb |
Related | 3V01 4U7Z 4U80 |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, ... (5 entities in total) |
Functional Keywords | kinase, complex, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q02750 |
Total number of polymer chains | 1 |
Total formula weight | 38830.50 |
Authors | Robarge, K.D.,Ultsch, M.H.,Weismann, C. (deposition date: 2014-07-31, release date: 2014-09-24, Last modification date: 2023-09-27) |
Primary citation | Robarge, K.D.,Lee, W.,Eigenbrot, C.,Ultsch, M.,Wiesmann, C.,Heald, R.,Price, S.,Hewitt, J.,Jackson, P.,Savy, P.,Burton, B.,Choo, E.F.,Pang, J.,Boggs, J.,Yang, A.,Yang, X.,Baumgardner, M. Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24:4714-4723, 2014 Cited by PubMed: 25193232DOI: 10.1016/j.bmcl.2014.08.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.701 Å) |
Structure validation
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