4U3B

LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2

Summary for 4U3B

Entry DOI	10.2210/pdb4u3b/pdb
Descriptor	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, IMIDAZOLE, ZINC ION, ... (6 entities in total)
Functional Keywords	antibacterial, lpxc, gram negative bacteria, mmp, hydrophobe, hydrolase
Biological source	Aquifex aeolicus
Total number of polymer chains	1
Total formula weight	31654.20
Authors	Olivier, N.B. (deposition date: 2014-07-19, release date: 2014-10-01, Last modification date: 2019-10-16)
Primary citation	Murphy-Benenato, K.E.,Olivier, N.,Choy, A.,Ross, P.L.,Miller, M.D.,Thresher, J.,Gao, N.,Hale, M.R. Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Med.Chem.Lett., 5:1213-1218, 2014 Cited by PubMed: 25408833 DOI: 10.1021/ml500210x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation