4TW8
The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL
Summary for 4TW8
Entry DOI | 10.2210/pdb4tw8/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP4, 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid (3 entities in total) |
Functional Keywords | fk-506 binding domain, hsp90 cochaperone, immunophiline, peptidyl-prolyl isomerase, ligand selectivity, isomerase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : Q02790 |
Total number of polymer chains | 2 |
Total formula weight | 55118.41 |
Authors | Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Almeida, O.F.X.,Ruehter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F. (deposition date: 2014-06-30, release date: 2014-11-26, Last modification date: 2023-12-20) |
Primary citation | Gaali, S.,Kirschner, A.,Cuboni, S.,Hartmann, J.,Kozany, C.,Balsevich, G.,Namendorf, C.,Fernandez-Vizarra, P.,Sippel, C.,Zannas, A.S.,Draenert, R.,Binder, E.B.,Almeida, O.F.,Ruhter, G.,Uhr, M.,Schmidt, M.V.,Touma, C.,Bracher, A.,Hausch, F. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11:33-37, 2015 Cited by PubMed: 25436518DOI: 10.1038/nchembio.1699 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.003 Å) |
Structure validation
Download full validation report