4TPK
Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
Summary for 4TPK
Entry DOI | 10.2210/pdb4tpk/pdb |
Related | 4BDS |
Descriptor | Cholinesterase, beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | butyrylcholinesterase inhibition, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 143427.96 |
Authors | Coquelle, N.,Brus, B.,Colletier, J.P.,Gobec, S. (deposition date: 2014-06-07, release date: 2014-10-22, Last modification date: 2024-05-01) |
Primary citation | Brus, B.,Kosak, U.,Turk, S.,Pislar, A.,Coquelle, N.,Kos, J.,Stojan, J.,Colletier, J.P.,Gobec, S. Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. J.Med.Chem., 57:8167-8179, 2014 Cited by PubMed: 25226236DOI: 10.1021/jm501195e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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