4RJ3
CDK2 with EGFR inhibitor compound 8
Summary for 4RJ3
Entry DOI | 10.2210/pdb4rj3/pdb |
Related | 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8 |
Descriptor | Cyclin-dependent kinase 2, ACETATE ION, 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, ... (4 entities in total) |
Functional Keywords | protein kinase, phosphotransfer catalyst, lysine acetylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34469.06 |
Authors | Eigenbrot, C.,Yin, J. (deposition date: 2014-10-08, release date: 2014-11-26, Last modification date: 2015-01-14) |
Primary citation | Hanan, E.J.,Eigenbrot, C.,Bryan, M.C.,Burdick, D.J.,Chan, B.K.,Chen, Y.,Dotson, J.,Heald, R.A.,Jackson, P.S.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Tam, C.,Wang, S.,Yeap, S.K.,Yen, I.,Yin, J.,Yu, C.,Zilberleyb, I.,Heffron, T.P. Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57:10176-10191, 2014 Cited by PubMed: 25383627DOI: 10.1021/jm501578n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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