4R5G
Crystal structure of the DnaK C-terminus with the inhibitor PET-16
Summary for 4R5G
Entry DOI | 10.2210/pdb4r5g/pdb |
Descriptor | Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium (3 entities in total) |
Functional Keywords | helical bundle, beta sheets, chaperone, hsp70/dnak inhibitors, membrane, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Escherichia coli |
Cellular location | Cytoplasm : P0A6Y8 |
Total number of polymer chains | 2 |
Total formula weight | 50838.16 |
Authors | Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. (deposition date: 2014-08-21, release date: 2014-09-10, Last modification date: 2023-09-20) |
Primary citation | Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9:2508-2516, 2014 Cited by PubMed: 25148104DOI: 10.1021/cb500236y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4501 Å) |
Structure validation
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