4R18
Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome
Summary for 4R18
Entry DOI | 10.2210/pdb4r18/pdb |
Related | 1RYP 4R17 |
Descriptor | PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT BETA TYPE-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (17 entities in total) |
Functional Keywords | proteasome, drug development, binding analysis, umpolung, crosslink, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae S288c (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 731524.37 |
Authors | Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Krueger, A.,Liskamp, R.,Groll, M. (deposition date: 2014-08-04, release date: 2014-10-15, Last modification date: 2023-12-06) |
Primary citation | Dubiella, C.,Cui, H.,Gersch, M.,Brouwer, A.J.,Sieber, S.A.,Kruger, A.,Liskamp, R.M.,Groll, M. Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angew.Chem.Int.Ed.Engl., 53:11969-11973, 2014 Cited by PubMed: 25244435DOI: 10.1002/anie.201406964 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report