4QXI
Crystal structure of human AR complexed with NADP+ and AK198
Summary for 4QXI
Entry DOI | 10.2210/pdb4qxi/pdb |
Related | 1US0 2IKI |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(4-amino-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, aldose reductase, oxidoreductase, diabetes, halogenated compound, cytosolic |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36994.49 |
Authors | Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Fanfrlik, J.,Hobza, P.,Podjarny, A.D. (deposition date: 2014-07-21, release date: 2015-07-22, Last modification date: 2023-11-08) |
Primary citation | Fanfrlik, J.,Ruiz, F.X.,Kadlcikova, A.,Rezac, J.,Cousido-Siah, A.,Mitschler, A.,Haldar, S.,Lepsik, M.,Kolar, M.H.,Majer, P.,Podjarny, A.D.,Hobza, P. The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. Acs Chem.Biol., 10:1637-1642, 2015 Cited by PubMed: 25919404DOI: 10.1021/acschembio.5b00151 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.867 Å) |
Structure validation
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