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4QQ6

Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule

Summary for 4QQ6
Entry DOI10.2210/pdb4qq6/pdb
DescriptorSurvival motor neuron protein, UNKNOWN ATOM OR ION, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, ... (4 entities in total)
Functional Keywordsstructural genomics, structural genomics consortium, sgc, rna binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q16637
Total number of polymer chains1
Total formula weight7597.57
Authors
Liu, Y.,Tempel, W.,Iqbal, A.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2014-06-26, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citationLiu, Y.,Iqbal, A.,Li, W.,Ni, Z.,Wang, Y.,Ramprasad, J.,Abraham, K.J.,Zhang, M.,Zhao, D.Y.,Qin, S.,Loppnau, P.,Jiang, H.,Guo, X.,Brown, P.J.,Zhen, X.,Xu, G.,Mekhail, K.,Ji, X.,Bedford, M.T.,Greenblatt, J.F.,Min, J.
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13:5453-5453, 2022
Cited by
PubMed: 36114190
DOI: 10.1038/s41467-022-33229-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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