4QO1
p53 DNA binding domain in complex with Nb139
Summary for 4QO1
| Entry DOI | 10.2210/pdb4qo1/pdb |
| Descriptor | Nb139 Nanobody against the DNA-binding domain of p53, Cellular tumor antigen p53, ZINC ION, ... (4 entities in total) |
| Functional Keywords | immunoglobulin fold, dna binding, apoptosis, transcription |
| Biological source | Lama glama (llama) More |
| Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
| Total number of polymer chains | 2 |
| Total formula weight | 42339.66 |
| Authors | De Gieter, S.,Bethuyne, J.,Gettemans, J.,Garcia-Pino, A.,Loris, R. (deposition date: 2014-06-19, release date: 2014-10-29, Last modification date: 2023-09-20) |
| Primary citation | Bethuyne, J.,De Gieter, S.,Zwaenepoel, O.,Garcia-Pino, A.,Durinck, K.,Verhelle, A.,Hassanzadeh-Ghassabeh, G.,Speleman, F.,Loris, R.,Gettemans, J. A nanobody modulates the p53 transcriptional program without perturbing its functional architecture. Nucleic Acids Res., 42:12928-12938, 2014 Cited by PubMed: 25324313DOI: 10.1093/nar/gku962 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.924 Å) |
Structure validation
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