4QLQ

yCP in complex with tripeptidic epoxyketone inhibitor 8

Summary for 4QLQ

• Entry DOI: 10.2210/pdb4qlq/pdb
• Related: 1G65 1RYP 4QLS 4QLT 4QLU 4QLV
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: proteasome, epoxyketone, immunoproteasome inhibitor, binding analysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 734381.10

Authors

De Bruin, G.,Huber, E.,Xin, B.,Van Rooden, E.,Al-Ayed, K.,Kim, K.,Kisselev, A.,Driessen, C.,Van der Marel, G.,Groll, M.,Overkleeft, H. (deposition date: 2014-06-13, release date: 2014-07-23, Last modification date: 2023-11-08)

• Primary citation: De Bruin, G.,Huber, E.M.,Xin, B.T.,Van Rooden, E.J.,Al-Ayed, K.,Kim, K.B.,Kisselev, A.F.,Driessen, C.,Van der Stelt, M.,Van der Marel, G.A.,Groll, M.,Overkleeft, H.S.; Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes; J.Med.Chem., 57:6197-6209, 2014; PubMed: 25006746; DOI: 10.1021/jm500716s

Experimental method

X-RAY DIFFRACTION (2.4 Å)