4QFR
Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor
Summary for 4QFR
Entry DOI | 10.2210/pdb4qfr/pdb |
Related | 4QFG 4QFS |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total) |
Functional Keywords | cbm, ampk, kinase, signaling protein-inhibitor-activator complex, signaling protein/inhibitor/activator |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cytoplasm : P54645 |
Total number of polymer chains | 3 |
Total formula weight | 120514.84 |
Authors | Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2014-05-21, release date: 2014-08-06, Last modification date: 2017-11-22) |
Primary citation | Calabrese, M.F.,Rajamohan, F.,Harris, M.S.,Caspers, N.L.,Magyar, R.,Withka, J.M.,Wang, H.,Borzilleri, K.A.,Sahasrabudhe, P.V.,Hoth, L.R.,Geoghegan, K.F.,Han, S.,Brown, J.,Subashi, T.A.,Reyes, A.R.,Frisbie, R.K.,Ward, J.,Miller, R.A.,Landro, J.A.,Londregan, A.T.,Carpino, P.A.,Cabral, S.,Smith, A.C.,Conn, E.L.,Cameron, K.O.,Qiu, X.,Kurumbail, R.G. Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22:1161-1172, 2014 Cited by PubMed: 25066137DOI: 10.1016/j.str.2014.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.34 Å) |
Structure validation
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