4QEV
Crystal structure of BRD2(BD2) mutant with ligand ME bound (METHYL (2R)- 2-[(4S)-6-(4-CHLOROPHENYL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1, 4]BENZODIAZEPIN-4-YL]PROPANOATE)
Summary for 4QEV
Entry DOI | 10.2210/pdb4qev/pdb |
Related | 4QEN 4QEP |
Descriptor | Bromodomain-containing protein 2, methyl (2R)-2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]propanoate, NONAETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | bromodomain-containing protein 2, kiaa9001, ring3, transcription regulation, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P25440 |
Total number of polymer chains | 1 |
Total formula weight | 14323.48 |
Authors | Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2014-05-19, release date: 2014-10-29, Last modification date: 2023-11-29) |
Primary citation | Baud, M.G.,Lin-Shiao, E.,Cardote, T.,Tallant, C.,Pschibul, A.,Chan, K.H.,Zengerle, M.,Garcia, J.R.,Kwan, T.T.,Ferguson, F.M.,Ciulli, A. Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science, 346:638-641, 2014 Cited by PubMed: 25323695DOI: 10.1126/science.1249830 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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