4QC6
Crystal structure of aminoglycoside 6'-acetyltransferase-Ie
Summary for 4QC6
Entry DOI | 10.2210/pdb4qc6/pdb |
Descriptor | Bifunctional AAC/APH, KANAMYCIN A, (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3,5-diphosphaheptadecane-17-sulfinic acid 3,5-dioxide (non-preferred name), ... (5 entities in total) |
Functional Keywords | antibiotic resistance, gnat family, acetyltransferase, acetylcoenzyme-a, aminoglycoside, transferase, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Staphylococcus warneri |
Cellular location | Cytoplasm : Q7ATH7 |
Total number of polymer chains | 2 |
Total formula weight | 46269.62 |
Authors | Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B. (deposition date: 2014-05-09, release date: 2014-10-22, Last modification date: 2024-02-28) |
Primary citation | Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B. Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis. Acta Crystallogr.,Sect.D, 70:2754-2764, 2014 Cited by PubMed: 25286858DOI: 10.1107/S1399004714017635 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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