4QBE

The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop

Summary for 4QBE

Entry DOI	10.2210/pdb4qbe/pdb
Related	4QAH 4QAP 4QBW
Descriptor	Tyrosine-protein phosphatase non-receptor type 1 (2 entities in total)
Functional Keywords	tyrosine phosphorylation, classic ptyr-specific ptp, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	34706.54
Authors	Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Bi, W.X. (deposition date: 2014-05-08, release date: 2014-12-24, Last modification date: 2024-03-20)
Primary citation	Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C:84-95, 2014 Cited by PubMed: 25450460 DOI: 10.1016/j.biocel.2014.10.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.292 Å)

Structure validation