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4Q2K

Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b

Summary for 4Q2K
Entry DOI10.2210/pdb4q2k/pdb
DescriptorChymotrypsinogen A, (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide (3 entities in total)
Functional Keywordschymotrypsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceBos taurus (bovine)
Cellular locationSecreted, extracellular space: P00766
Total number of polymer chains4
Total formula weight105174.93
Authors
Chan, H.Y.,Bruning, J.B.,Abell, A.D. (deposition date: 2014-04-09, release date: 2014-07-23, Last modification date: 2023-11-08)
Primary citationChua, K.C.,Pietsch, M.,Zhang, X.,Hautmann, S.,Chan, H.Y.,Bruning, J.B.,Gutschow, M.,Abell, A.D.
Macrocyclic protease inhibitors with reduced peptide character.
Angew.Chem.Int.Ed.Engl., 53:7828-7831, 2014
Cited by
PubMed: 24903745
DOI: 10.1002/anie.201404301
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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