4PV7
Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor
Summary for 4PV7
Entry DOI | 10.2210/pdb4pv7/pdb |
Descriptor | Dipeptidyl peptidase 4 soluble form, 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine (2 entities in total) |
Functional Keywords | beta-propeller, hydrolase, extrocellular side, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487 |
Total number of polymer chains | 2 |
Total formula weight | 175329.77 |
Authors | |
Primary citation | Xiao, P.,Guo, R.,Huang, S.,Cui, H.,Ye, S.,Zhang, Z. Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett., 25:673-676, 2014 Cited by DOI: 10.1016/j.cclet.2014.03.047PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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