4PP7
Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase
Summary for 4PP7
Entry DOI | 10.2210/pdb4pp7/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide (2 entities in total) |
Functional Keywords | serine/threonine-protein kinase b-raf, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71280.16 |
Authors | Wenglowsky, S.,Ren, L.,Grina, J.,Hansen, J.D.,Laird, E.R.,Moreno, D.,Dinkel, V.,Gloor, S.L.,Hastings, G.,Rana, S.,Rasor, K.,Sturgis, H.L.,Voegtli, W.C.,Vigers, G.P.A.,Willis, B.,Mathieu, S.,Rudolph, J. (deposition date: 2014-02-26, release date: 2014-04-09, Last modification date: 2024-02-28) |
Primary citation | Wenglowsky, S.,Ren, L.,Grina, J.,Hansen, J.D.,Laird, E.R.,Moreno, D.,Dinkel, V.,Gloor, S.L.,Hastings, G.,Rana, S.,Rasor, K.,Sturgis, H.L.,Voegtli, W.C.,Vigers, G.,Willis, B.,Mathieu, S.,Rudolph, J. Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 24:1923-1927, 2014 Cited by PubMed: 24675381DOI: 10.1016/j.bmcl.2014.03.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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