4PDW
A benzonitrile analogue inhibits rhinovirus replication
Summary for 4PDW
Entry DOI | 10.2210/pdb4pdw/pdb |
Descriptor | Genome polyprotein, Capsid protein VP4/VP2, GLYCEROL, ... (7 entities in total) |
Functional Keywords | benzonitrile inhibitor, virus |
Biological source | Human rhinovirus 14 (HRV-14) More |
Cellular location | Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03303 P03303 P03303 |
Total number of polymer chains | 4 |
Total formula weight | 95177.21 |
Authors | Querol-Audi, J.,Guerra, P.,Lacroix, C.,Roche, M.,Franco, D.,Froeyen, M.,Terme, T.,Vanelle, P.,Neyts, J.,Leyssen, P.,Verdaguer, N. (deposition date: 2014-04-22, release date: 2014-07-02, Last modification date: 2023-12-20) |
Primary citation | Lacroix, C.,Querol-Audi, J.,Roche, M.,Franco, D.,Froeyen, M.,Guerra, P.,Terme, T.,Vanelle, P.,Verdaguer, N.,Neyts, J.,Leyssen, P. A novel benzonitrile analogue inhibits rhinovirus replication. J.Antimicrob.Chemother., 69:2723-2732, 2014 Cited by PubMed: 24948704DOI: 10.1093/jac/dku200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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