4P72
PheRS in complex with compound 2a
Summary for 4P72
Entry DOI | 10.2210/pdb4p72/pdb |
Related | 4P71 4P73 4P74 4P75 |
Descriptor | Phenylalanine--tRNA ligase beta subunit, Phenylalanine--tRNA ligase alpha subunit, 2-{3-[(4-chloropyridin-2-yl)amino]phenoxy}-N-methylacetamide, ... (4 entities in total) |
Functional Keywords | phenylalanine trna synthetase, phers, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Pseudomonas aeruginosa More |
Cellular location | Cytoplasm : Q9I0A4 Q9I0A3 |
Total number of polymer chains | 4 |
Total formula weight | 250610.94 |
Authors | Ferguson, A.D. (deposition date: 2014-03-25, release date: 2014-06-25, Last modification date: 2023-09-27) |
Primary citation | Abibi, A.,Ferguson, A.D.,Fleming, P.R.,Gao, N.,Hajec, L.I.,Hu, J.,Laganas, V.A.,McKinney, D.C.,McLeod, S.M.,Prince, D.B.,Shapiro, A.B.,Buurman, E.T. The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability. J.Biol.Chem., 289:21651-21662, 2014 Cited by PubMed: 24936059DOI: 10.1074/jbc.M114.574061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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