4P45

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor JRB-4-73

Summary for 4P45

Entry DOI	10.2210/pdb4p45/pdb
Descriptor	Glutamate carboxypeptidase 2, N-(4-fluorobenzoyl)-L-valyl-O-[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]-L-serine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, phosphoramidate, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
Total number of polymer chains	1
Total formula weight	83699.64
Authors	Novakova, Z.,Barinka, C. (deposition date: 2014-03-11, release date: 2015-05-20, Last modification date: 2020-07-29)
Primary citation	Novakova, Z.,Cerny, J.,Choy, C.J.,Nedrow, J.R.,Choi, J.K.,Lubkowski, J.,Berkman, C.E.,Barinka, C. Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities. Febs J., 283:130-143, 2016 Cited by PubMed: 26460595 DOI: 10.1111/febs.13557 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation