4P3X

Structure of the Fe4S4 quinolinate synthase NadA from Thermotoga maritima

Summary for 4P3X

Entry DOI	10.2210/pdb4p3x/pdb
Related	1WZU 4HHE
Descriptor	Quinolinate synthase A, IRON/SULFUR CLUSTER, ZINC ION, ... (5 entities in total)
Functional Keywords	holo-protein, nad biosynthesis, catalytic triad, iron sulfur cluster, transferase
Biological source	Thermotoga maritima
Cellular location	Cytoplasm : Q9X1X7
Total number of polymer chains	1
Total formula weight	35309.99
Authors	Cherrier, M.V.,Chan, A.,Darnault, C.,Reichmann, D.,Amara, P.,Ollagnier de Choudens, S.,Fontecilla-Camps, J.C. (deposition date: 2014-03-10, release date: 2014-04-02, Last modification date: 2023-09-27)
Primary citation	Cherrier, M.V.,Chan, A.,Darnault, C.,Reichmann, D.,Amara, P.,Ollagnier de Choudens, S.,Fontecilla-Camps, J.C. The crystal structure of Fe4S4 quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad. J.Am.Chem.Soc., 136:5253-5256, 2014 Cited by PubMed: 24650327 DOI: 10.1021/ja501431b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation