4OQR

Structure of a CYP105AS1 mutant in complex with compactin

Summary for 4OQR

Entry DOI	10.2210/pdb4oqr/pdb
Related	4OQS
Descriptor	CYP105AS1, PROTOPORPHYRIN IX CONTAINING FE, Mevastatin, Compactin, ... (4 entities in total)
Functional Keywords	cytochrome p450, monooxygenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Amycolatopsis orientalis
Total number of polymer chains	1
Total formula weight	51635.78
Authors	Leys, D. (deposition date: 2014-02-10, release date: 2015-02-18, Last modification date: 2024-04-03)
Primary citation	McLean, K.J.,Hans, M.,Meijrink, B.,van Scheppingen, W.B.,Vollebregt, A.,Tee, K.L.,van der Laan, J.M.,Leys, D.,Munro, A.W.,van den Berg, M.A. Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc.Natl.Acad.Sci.USA, 112:2847-2852, 2015 Cited by PubMed: 25691737 DOI: 10.1073/pnas.1419028112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation