4O0V

Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors

Summary for 4O0V

• Entry DOI: 10.2210/pdb4o0v/pdb
• Related: 4O0R 4O0T 4O0X 4O0Y
• Descriptor: Serine/threonine-protein kinase PAK 4, 1-({1-(2-aminopyrimidin-4-yl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl}ethynyl)cyclohexanol (3 entities in total)
• Functional Keywords: pak4, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O96013
• Total number of polymer chains: 1
• Total formula weight: 33474.90

Authors

Rouge, L.,Tam, C.,Wang, W. (deposition date: 2013-12-14, release date: 2014-02-12, Last modification date: 2014-02-26)

• Primary citation: Staben, S.T.,Feng, J.A.,Lyle, K.,Belvin, M.,Boggs, J.,Burch, J.D.,Chua, C.C.,Cui, H.,Dipasquale, A.G.,Friedman, L.S.,Heise, C.,Koeppen, H.,Kotey, A.,Mintzer, R.,Oh, A.,Roberts, D.A.,Rouge, L.,Rudolph, J.,Tam, C.,Wang, W.,Xiao, Y.,Young, A.,Zhang, Y.,Hoeflich, K.P.; Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.; J.Med.Chem., 57:1033-1045, 2014; PubMed: 24432870; DOI: 10.1021/jm401768t

Experimental method

X-RAY DIFFRACTION (2.8 Å)