4NYJ
Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange
Summary for 4NYJ
Entry DOI | 10.2210/pdb4nyj/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | gtpase, signaling transduction, raf, ralgds, pi3k, cytosol, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 P01112 |
Total number of polymer chains | 3 |
Total formula weight | 95023.89 |
Authors | Burns, M.C.,Sun, Q.,Phan, J.,Fesik, S.W. (deposition date: 2013-12-10, release date: 2014-03-12, Last modification date: 2023-09-20) |
Primary citation | Burns, M.C.,Sun, Q.,Daniels, R.N.,Camper, D.,Kennedy, J.P.,Phan, J.,Olejniczak, E.T.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111:3401-3406, 2014 Cited by PubMed: 24550516DOI: 10.1073/pnas.1315798111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8522 Å) |
Structure validation
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