4NQD

Crystal structure of TCR-MR1 ternary complex and non-covalently bound 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil

Summary for 4NQD

• Entry DOI: 10.2210/pdb4nqd/pdb
• Related: 4GUP 4L4V 4NQC 4NQE
• Descriptor: Major histocompatibility complex class I-related gene protein, Beta-2-microglobulin, TCR alpha chain, ... (7 entities in total)
• Functional Keywords: immune complex, mr1, t-cell receptor, ig-domain, protein binding, schiff base, membrane, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass membrane protein; Extracellular side. Isoform 4: Secreted. Isoform 3: Cell membrane ; Single-pass type I membrane protein : Q95460; Secreted : P61769
• Total number of polymer chains: 8
• Total formula weight: 188065.61

Authors

Birkinshaw, R.W.,Rossjohn, J. (deposition date: 2013-11-25, release date: 2014-04-16, Last modification date: 2014-11-19)

• Primary citation: Corbett, A.J.,Eckle, S.B.,Birkinshaw, R.W.,Liu, L.,Patel, O.,Mahony, J.,Chen, Z.,Reantragoon, R.,Meehan, B.,Cao, H.,Williamson, N.A.,Strugnell, R.A.,Van Sinderen, D.,Mak, J.Y.,Fairlie, D.P.,Kjer-Nielsen, L.,Rossjohn, J.,McCluskey, J.; T-cell activation by transitory neo-antigens derived from distinct microbial pathways.; Nature, 509:361-365, 2014; PubMed: 24695216; DOI: 10.1038/nature13160

Experimental method

X-RAY DIFFRACTION (2.2 Å)