4NQ6

Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound L-CS319

Summary for 4NQ6

• Entry DOI: 10.2210/pdb4nq6/pdb
• Related: 4NQ4 4NQ5 4NQ6 4NQ7
• Descriptor: Beta-lactamase 2, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: lactamase, metallo-beta-lactamase superfamily, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bacillus cereus
• Cellular location: Periplasm : P04190
• Total number of polymer chains: 1
• Total formula weight: 24830.18

Authors

Gonzalez, J.M.,Gonzalez, M.M.,Vila, A.J. (deposition date: 2013-11-23, release date: 2014-11-26, Last modification date: 2024-02-28)

• Primary citation: Hinchliffe, P.,Gonzalez, M.M.,Mojica, M.F.,Gonzalez, J.M.,Castillo, V.,Saiz, C.,Kosmopoulou, M.,Tooke, C.L.,Llarrull, L.I.,Mahler, G.,Bonomo, R.A.,Vila, A.J.,Spencer, J.; Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.; Proc. Natl. Acad. Sci. U.S.A., 113:E3745-E3754, 2016; PubMed: 27303030; DOI: 10.1073/pnas.1601368113

Experimental method

X-RAY DIFFRACTION (1.8 Å)