4NMM

Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor

Summary for 4NMM

Entry DOI	10.2210/pdb4nmm/pdb
Related	4LDJ 4OBE
Descriptor	GTPase KRas, MAGNESIUM ION, 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, ... (4 entities in total)
Functional Keywords	small gtpase, gdp bound, oncogenic mutation, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
Total number of polymer chains	1
Total formula weight	19927.51
Authors	Hunter, J.C.,Gurbani, D.,Lim, S.M.,Westover, K.D. (deposition date: 2013-11-15, release date: 2014-06-04, Last modification date: 2023-09-20)
Primary citation	Hunter, J.C.,Gurbani, D.,Ficarro, S.B.,Carrasco, M.A.,Lim, S.M.,Choi, H.G.,Xie, T.,Marto, J.A.,Chen, Z.,Gray, N.S.,Westover, K.D. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111:8895-8900, 2014 Cited by PubMed: 24889603 DOI: 10.1073/pnas.1404639111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation