4MZR

Crystal structure of a polypeptide p53 mutant bound to DNA

Summary for 4MZR

Entry DOI	10.2210/pdb4mzr/pdb
Related	4MZI
Descriptor	Cellular tumor antigen p53, consensus DNA sense strand, consensus DNA anti-sense strand, ... (5 entities in total)
Functional Keywords	p53, tumor suppressor, protein-dna complex, dna binding, multidomain, oligomerization, antitumor protein/dna, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	124340.09
Authors	Emamzadah, S.T.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. (deposition date: 2013-09-30, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	Emamzadah, S.,Tropia, L.,Vincenti, I.,Falquet, B.,Halazonetis, T.D. Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426:936-944, 2014 Cited by PubMed: 24374182 DOI: 10.1016/j.jmb.2013.12.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation