4MY6

EnaH-EVH1 in complex with peptidomimetic low-molecular weight inhibitor Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-OH

Summary for 4MY6

• Entry DOI: 10.2210/pdb4my6/pdb
• Related PRD ID: PRD_001198
• Descriptor: Protein enabled homolog, (3aR,5aS,8S,10aS)-1-[(3S,6R,8aS)-1'-[(2S)-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8a-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-10-oxidanylidene-2,3,3a,5a,8,10a-hexahydrodipyrrolo[3,2-b:3',1'-f]azepine-8-carboxylic acid, BROMIDE ION, ... (4 entities in total)
• Functional Keywords: molecular recognition, actin dynamics, cell adhesion-inhibitor complex, cell adhesion/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q8N8S7
• Total number of polymer chains: 2
• Total formula weight: 26768.67

Authors

Barone, M.,Roske, Y.,Kuehne, R. (deposition date: 2013-09-27, release date: 2014-10-15, Last modification date: 2023-09-20)

• Primary citation: Opitz, R.,Muller, M.,Reuter, C.,Barone, M.,Soicke, A.,Roske, Y.,Piotukh, K.,Huy, P.,Beerbaum, M.,Wiesner, B.,Beyermann, M.,Schmieder, P.,Freund, C.,Volkmer, R.,Oschkinat, H.,Schmalz, H.G.,Kuhne, R.; A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.; Proc.Natl.Acad.Sci.USA, 112:5011-5016, 2015; PubMed: 25848013; DOI: 10.1073/pnas.1422054112

Experimental method

X-RAY DIFFRACTION (1.7 Å)