4MRD

Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule

Summary for 4MRD

Entry DOI	10.2210/pdb4mrd/pdb
Related	4MRE 4MRF 4MRG 4MRH 4NP2 4NP3
Descriptor	CD44 antigen, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total)
Functional Keywords	link module, cell receptor, hyaluronan binding, cell surface, cell adhesion
Biological source	Mus musculus (mouse)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P15379
Total number of polymer chains	1
Total formula weight	17483.21
Authors	Liu, L.K.,Finzel, B. (deposition date: 2013-09-17, release date: 2014-04-16, Last modification date: 2020-07-29)
Primary citation	Liu, L.K.,Finzel, B.C. Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57:2714-2725, 2014 Cited by PubMed: 24606063 DOI: 10.1021/jm5000276 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation