4MQY
Crystal Structure of the Escherichia coli LpxC/LPC-138 complex
Summary for 4MQY
| Entry DOI | 10.2210/pdb4mqy/pdb |
| Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-2-methyl-1-nitroso-1-oxobutan-2-yl]benzamide, ... (7 entities in total) |
| Functional Keywords | lpxc, antibiotic, acyl udp-glcnac, hydroxamate, lpc-138, baab sandwich, lipid a biosynthesis, lipid a synthesis, deacetylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 35269.38 |
| Authors | Lee, C.-J.,Najeeb, J.,Zhou, P. (deposition date: 2013-09-17, release date: 2013-10-23, Last modification date: 2024-02-28) |
| Primary citation | Lee, C.J.,Liang, X.,Gopalaswamy, R.,Najeeb, J.,Ark, E.D.,Toone, E.J.,Zhou, P. Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC. Acs Chem.Biol., 9:237-246, 2014 Cited by PubMed: 24117400DOI: 10.1021/cb400067g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.005 Å) |
Structure validation
Download full validation report
