4MJO
Human liver fructose-1,6-bisphosphatase(d-fructose-1,6-bisphosphate, 1-phosphohydrolase) (e.c.3.1.3.11) complexed with the allosteric inhibitor 3
Summary for 4MJO
Entry DOI | 10.2210/pdb4mjo/pdb |
Related | 2jjk 2vt5 |
Descriptor | Fructose-1,6-bisphosphatase 1, N-({4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl}carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide (3 entities in total) |
Functional Keywords | allostery, hydrolase (phosphoric monoester), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 8 |
Total formula weight | 299150.63 |
Authors | Ruf, A.,Joseph, C.,Tetaz, T.,Benz, J. (deposition date: 2013-09-04, release date: 2013-11-06, Last modification date: 2023-09-20) |
Primary citation | Cubrilovic, D.,Haap, W.,Barylyuk, K.,Ruf, A.,Badertscher, M.,Gubler, M.,Tetaz, T.,Joseph, C.,Benz, J.,Zenobi, R. Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry. Acs Chem.Biol., 9:218-226, 2014 Cited by PubMed: 24128068DOI: 10.1021/cb4007002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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