4MFB
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor
Summary for 4MFB
Entry DOI | 10.2210/pdb4mfb/pdb |
Related | 1S9E 4H4M 4H4O 4KKO 4LSL 4LSN |
Descriptor | HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile, ... (4 entities in total) |
Functional Keywords | polymerase, transferase, hydrolase, rnaseh, rnase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114417.10 |
Authors | Frey, K.M.,Anderson, K.S. (deposition date: 2013-08-27, release date: 2013-11-06, Last modification date: 2023-09-20) |
Primary citation | Lee, W.G.,Gallardo-Macias, R.,Frey, K.M.,Spasov, K.A.,Bollini, M.,Anderson, K.S.,Jorgensen, W.L. Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group. J.Am.Chem.Soc., 135:16705-16713, 2013 Cited by PubMed: 24151856DOI: 10.1021/ja408917n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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