4MCV
Star 12 bound to analog-sensitive Src kinase
Summary for 4MCV
Entry DOI | 10.2210/pdb4mcv/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, (7S)-12-(4-aminobutyl)-7-(2-methylpropyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (2 entities in total) |
Functional Keywords | kinase domain, tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Gallus gallus (bantam,chickens) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 64534.39 |
Authors | Lopez, M.S.,Shokat, K.M. (deposition date: 2013-08-21, release date: 2013-11-20, Last modification date: 2024-02-28) |
Primary citation | Lopez, M.S.,Choy, J.W.,Peters, U.,Sos, M.L.,Morgan, D.O.,Shokat, K.M. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J.Am.Chem.Soc., 135:18153-18159, 2013 Cited by PubMed: 24171479DOI: 10.1021/ja408704u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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