4M3Q
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917
Summary for 4M3Q
Entry DOI | 10.2210/pdb4m3q/pdb |
Related | 2BRB 2POC 3BPR 3TCP |
Descriptor | Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | tyrosine kinase, acute lymphoblastic leukemia, rational structure-based drug design, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type I membrane protein : Q12866 |
Total number of polymer chains | 2 |
Total formula weight | 72734.25 |
Authors | Zhang, W.,Zhang, D.,Stashko, M.A.,DeRyckere, D.,Hunter, D.,Kireev, D.B.,Miley, M.,Cummings, C.,Lee, M.,Norris-Drouin, J.,Stewart, W.M.,Sather, S.,Zhou, Y.,Kirkpatrick, G.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.,Wang, X. (deposition date: 2013-08-06, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Zhang, W.,Zhang, D.,Stashko, M.A.,Deryckere, D.,Hunter, D.,Kireev, D.,Miley, M.J.,Cummings, C.,Lee, M.,Norris-Drouin, J.,Stewart, W.M.,Sather, S.,Zhou, Y.,Kirkpatrick, G.,Machius, M.,Janzen, W.P.,Earp, H.S.,Graham, D.K.,Frye, S.V.,Wang, X. Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors. J.Med.Chem., 56:9683-9692, 2013 Cited by PubMed: 24195762DOI: 10.1021/jm401387j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.718 Å) |
Structure validation
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