4LY1
Structure of Human HDAC2 in complex with inhibitor 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide
Summary for 4LY1
Entry DOI | 10.2210/pdb4ly1/pdb |
Related | 4LXZ |
Descriptor | Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | deacetylase, histone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q92769 |
Total number of polymer chains | 3 |
Total formula weight | 130302.50 |
Authors | Fong, R.,Lupardus, P.J. (deposition date: 2013-07-30, release date: 2013-08-21, Last modification date: 2023-09-20) |
Primary citation | Lauffer, B.E.,Mintzer, R.,Fong, R.,Mukund, S.,Tam, C.,Zilberleyb, I.,Flicke, B.,Ritscher, A.,Fedorowicz, G.,Vallero, R.,Ortwine, D.F.,Gunzner, J.,Modrusan, Z.,Neumann, L.,Koth, C.M.,Lupardus, P.J.,Kaminker, J.S.,Heise, C.E.,Steiner, P. Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. J.Biol.Chem., 288:26926-26943, 2013 Cited by PubMed: 23897821DOI: 10.1074/jbc.M113.490706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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