4LUW
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
Summary for 4LUW
| Entry DOI | 10.2210/pdb4luw/pdb |
| Related | 4LUX 4LWA 4LWB |
| Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
| Functional Keywords | nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Bos taurus (bovine) |
| Cellular location | Cell membrane : P29473 |
| Total number of polymer chains | 2 |
| Total formula weight | 102055.78 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2013-07-25, release date: 2013-10-23, Last modification date: 2023-09-20) |
| Primary citation | Holden, J.K.,Li, H.,Jing, Q.,Kang, S.,Richo, J.,Silverman, R.B.,Poulos, T.L. Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proc.Natl.Acad.Sci.USA, 110:18127-18131, 2013 Cited by PubMed: 24145412DOI: 10.1073/pnas.1314080110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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