4LRR
Ternary complex between E. coli thymidylate synthase, dUMP, and F9
Summary for 4LRR
Entry DOI | 10.2210/pdb4lrr/pdb |
Related | 4LRP |
Descriptor | Thymidylate synthase, SULFATE ION, 2-oxo-2H-naphtho[1,8-bc]furan-6-yl 4-nitrobenzoate, ... (5 entities in total) |
Functional Keywords | thymidine monophosphate synthesis, n-terminal acetylated methionine, beta-mercaptoethanol modified cysteine, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm (By similarity): P0A886 |
Total number of polymer chains | 1 |
Total formula weight | 31999.74 |
Authors | Mangani, S.,Pozzi, C.,Ferrari, S.,Costi, M.P. (deposition date: 2013-07-20, release date: 2013-11-06, Last modification date: 2013-12-11) |
Primary citation | Ferrari, S.,Calo, S.,Leone, R.,Luciani, R.,Costantino, L.,Sammak, S.,Di Pisa, F.,Pozzi, C.,Mangani, S.,Costi, M.P. 2'-Deoxyuridine 5'-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives. J.Med.Chem., 56:9356-9360, 2013 Cited by PubMed: 24147825DOI: 10.1021/jm4014086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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