4LPH
Crystal structure of human FPPS in complex with CL03093
Summary for 4LPH
Entry DOI | 10.2210/pdb4lph/pdb |
Related | 4LPG |
Descriptor | Farnesyl pyrophosphate synthase, PHOSPHATE ION, ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl)phosphonic acid, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43575.27 |
Authors | Park, J.,Leung, C.Y.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2013-07-16, release date: 2014-06-25, Last modification date: 2023-09-20) |
Primary citation | De Schutter, J.W.,Park, J.,Leung, C.Y.,Gormley, P.,Lin, Y.S.,Hu, Z.,Berghuis, A.M.,Poirier, J.,Tsantrizos, Y.S. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. J.Med.Chem., 57:5764-5776, 2014 Cited by PubMed: 24911527DOI: 10.1021/jm500629e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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