4LGG

Structure of 3MB-PP1 bound to analog-sensitive Src kinase

Summary for 4LGG

• Entry DOI: 10.2210/pdb4lgg/pdb
• Related: 4LGH
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (bantam,chickens)
• Cellular location: Cell membrane : P00523
• Total number of polymer chains: 2
• Total formula weight: 62423.99

Authors

Lopez, M.S.,Dar, A.C.,Shokat, K.M. (deposition date: 2013-06-27, release date: 2013-08-07, Last modification date: 2024-02-28)

• Primary citation: Zhang, C.,Lopez, M.S.,Dar, A.C.,Ladow, E.,Finkbeiner, S.,Yun, C.H.,Eck, M.J.,Shokat, K.M.; Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.; Acs Chem.Biol., 8:1931-1938, 2013; PubMed: 23841803; DOI: 10.1021/cb400376p

Experimental method

X-RAY DIFFRACTION (2.41 Å)