4L7N
Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542
Summary for 4L7N
Entry DOI | 10.2210/pdb4l7n/pdb |
Related | 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7O 4L7P 4L7R 4L7U |
Descriptor | Poly [ADP-ribose] polymerase 3, 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(4-sulfamoylphenyl)ethyl]propanamide (3 entities in total) |
Functional Keywords | diphtheria toxin like adp-ribose transferase, transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9Y6F1 |
Total number of polymer chains | 1 |
Total formula weight | 40152.53 |
Authors | Karlberg, T.,Thorsell, A.G.,Lindgren, A.E.G.,Ekblad, T.,Spjut, S.,Andersson, C.D.,Weigelt, J.,Linusson, A.,Elofsson, M.,Schuler, H. (deposition date: 2013-06-14, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Lindgren, A.E.,Karlberg, T.,Ekblad, T.,Spjut, S.,Thorsell, A.G.,Andersson, C.D.,Nhan, T.T.,Hellsten, V.,Weigelt, J.,Linusson, A.,Schuler, H.,Elofsson, M. Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56:9556-9568, 2013 Cited by PubMed: 24188023DOI: 10.1021/jm401394u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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