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4KCL

Structure of neuronal nitric oxide synthase heme domain in complex with N-(4-(2-((3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide

Summary for 4KCL
Entry DOI10.2210/pdb4kcl/pdb
Related4KCH 4KCI 4KCJ 4KCK 4KCM 4KCN 4KCO 4KCP 4KCQ 4KCR 4KCS
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (rat)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100443.28
Authors
Li, H.,Poulos, T.L. (deposition date: 2013-04-24, release date: 2014-02-12, Last modification date: 2023-09-20)
Primary citationHuang, H.,Li, H.,Yang, S.,Chreifi, G.,Martasek, P.,Roman, L.J.,Meyskens, F.L.,Poulos, T.L.,Silverman, R.B.
Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.
J.Med.Chem., 57:686-700, 2014
Cited by
PubMed: 24447275
DOI: 10.1021/jm401252e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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