4IWV
Crystals structure of Human Glucokinase in complex with small molecule activator
Summary for 4IWV
Entry DOI | 10.2210/pdb4iwv/pdb |
Descriptor | Glucokinase isoform 3, SODIUM ION, alpha-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | allosteric site, catalysis, enzyme activation, gene expression regulation, glucokinase, glucose, homeostasis, humans, hypoglycemia, kinetics, biological, models, molecular, mutation, protein conformation, scattering, radiation, x-rays, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 51500.14 |
Authors | Ogg, D.J.,Hargreaves, D.,Gerhardt, S.,Flavell, L.,McAlister, M. (deposition date: 2013-01-24, release date: 2013-04-24, Last modification date: 2023-09-20) |
Primary citation | Waring, M.J.,Bennett, S.N.,Boyd, S.,Campbell, L.,Davies, R.D.M.,Ogg, D.J.,Hargreaves, D.,Martin, N.G.,Robb, G.,Wilkinson, S.,MacPaul, P.,Wood, J.M. Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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