4INB

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With benzodiazepine Inhibitor

Summary for 4INB

Entry DOI	10.2210/pdb4inb/pdb
Related	4E91 4E92
Descriptor	Gag protein, (3Z)-3-{[(2-methoxyethyl)amino]methylidene}-1-methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione, SODIUM ION, ... (4 entities in total)
Functional Keywords	structural protein, capsid, viral protein, viral protein-viral protein inhibitor complex, viral protein/viral protein inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Capsid protein p24: Virion (By similarity). Matrix protein p17: Virion (By similarity). Nucleocapsid protein p7: Virion (By similarity): Q79791
Total number of polymer chains	1
Total formula weight	16646.96
Authors	Coulombe, R. (deposition date: 2013-01-04, release date: 2013-02-27, Last modification date: 2024-02-28)
Primary citation	Goudreau, N.,Coulombe, R.,Faucher, A.M.,Grand-Maitre, C.,Lacoste, J.E.,Lemke, C.T.,Malenfant, E.,Bousquet, Y.,Fader, L.,Simoneau, B.,Mercier, J.F.,Titolo, S.,Mason, S.W. Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using (19) F Ligand-and (15) N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series. Chemmedchem, 8:405-414, 2013 Cited by PubMed: 23401268 DOI: 10.1002/cmdc.201200580 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation