4IN4
Crystal structure of cpd 15 bound to Keap1 Kelch domain
Summary for 4IN4
Entry DOI | 10.2210/pdb4in4/pdb |
Related | 4IQK |
Descriptor | Kelch-like ECH-associated protein 1, PHOSPHATE ION, 2-({5-[(2,4-dimethylphenyl)sulfonyl]-6-oxo-1,6-dihydropyrimidin-2-yl}sulfanyl)-N-[2-(trifluoromethyl)phenyl]acetamide, ... (4 entities in total) |
Functional Keywords | transcription |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q14145 |
Total number of polymer chains | 3 |
Total formula weight | 101780.53 |
Authors | Silvian, L.,Marcotte, D. (deposition date: 2013-01-03, release date: 2013-05-15, Last modification date: 2023-09-20) |
Primary citation | Marcotte, D.,Zeng, W.,Hus, J.C.,McKenzie, A.,Hession, C.,Jin, P.,Bergeron, C.,Lugovskoy, A.,Enyedy, I.,Cuervo, H.,Wang, D.,Atmanene, C.,Roecklin, D.,Vecchi, M.,Vivat, V.,Kraemer, J.,Winkler, D.,Hong, V.,Chao, J.,Lukashev, M.,Silvian, L. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg.Med.Chem., 21:4011-4019, 2013 Cited by PubMed: 23647822DOI: 10.1016/j.bmc.2013.04.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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