4IGF
Crystal structure of Plasmodium falciparum FabI complexed with NAD and inhibitor 3-(4-Chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one
Summary for 4IGF
Entry DOI | 10.2210/pdb4igf/pdb |
Related | 4IGE |
Descriptor | Enoyl-acyl carrier reductase, 3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 80943.15 |
Authors | Kostrewa, D.,Perozzo, R. (deposition date: 2012-12-17, release date: 2013-11-06, Last modification date: 2023-11-08) |
Primary citation | Belluti, F.,Perozzo, R.,Lauciello, L.,Colizzi, F.,Kostrewa, D.,Bisi, A.,Gobbi, S.,Rampa, A.,Bolognesi, M.L.,Recanatini, M.,Brun, R.,Scapozza, L.,Cavalli, A. Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors of Plasmodium falciparum Enoyl-ACP-reductase (PfFabI) J.Med.Chem., 56:7516-7526, 2013 Cited by PubMed: 24063369DOI: 10.1021/jm400637m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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